Isoquinolone Compounds as Subtype-Selective Agonists for Melatonin Receptors MT1 and MT2
A method of treating preventing or ameliorating a pathological condition associated with a melatonin receptor in a mammal by using a pharmaceutical composition containing a compound of formula (I) as a ligand interacting with the melatonin receptor R1 R2 R3 R4 and R7 are independently H halo alkyloxyl alkyl or hydroxyl provided that one of R1 R2 R3 and R7 is X(CH2)nR8; R5 is alkyl or arylalkyl; R6 is H or alkyl; X is a bond O S SO SO2 CO or NH; n=0-10; R8 is alkenyl substituted or unsubstituted aryl NR9R10 or OR9; R9 is H substituted or unsubstituted arylmethyl or alkenyl; and R10 is H or alkyl.
Countries or Regions:
US
Invention Code:
IP.PA.00287
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okt@ust.hk
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Category:
TAP - Biotechnology
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